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LSU Health Shreveport
Department of Pharmacology, Toxicology and Neuroscience​​​​​​​
1501 Kings Hwy
Shreveport, LA 71103

 

Email:
hnam@lsuhsc.edu
Office:
(318) 675-3241
Website

Hyung W. Nam, PhD

Assistant Professor of Pharmacology, Toxicology and Neuroscience

 
PhD, 2006, Biochemistry - Yonsei University, Seoul, Korea
Post-Doctoral Fellow, Molecular Pharmacology and Psychiatry - Mayo Clinic, Rochester, MN
 

 

Research

Major Research Interests

 
Neuropharmacology of Alcoholism and Psychiatric Disorders, Neuroproteomics
 
The main goal of our research is to investigate brain molecular/cellular signaling in alcoholism and psychiatric disorders by using a behavioral neuroscience approach. Interestingly, both genetic and environmental factors contribute to alcoholism, influenced susceptibility, and treatment responsiveness. Thus, we believe that linking addictive behaviors with a neuromodulation process and also intracellular mechanisms are essential to understanding psychiatric symptoms and how to better treat them. The focus of our research is to elucidate molecular mechanism that underline relevant addictive behavioral phenotypes in rodent models using a combination of cutting-edge techniques in the areas of optogenetics, neuroproteomics, neuropharmacology, and behavioral neuroscience.
 
Adenosine-glutamate signaling in alcoholism and neuro-glia interaction.
We have investigated adenosine-glutamate signaling mechanisms that result in neuro-glia dysregulation induced by excessive alcohol exposure. Using proteomics, we are investigating the glutamate synaptic plasticity modulated by adenosine 2A receptor (Adora2A) and neurogranin (Nrgn) in the striatum, which is regulated by extracellular adenosine levels in the brain. In particular, we are interested in the decision-making process associated with addiction development by utilizing advanced operant conditioning.  The behavioral mechanism behind the progression from the initial stages of goal-directed drug use to compulsive drug taking is a major question in my research. To address this goal, we have developed novel transgenic mice that are the most clinically relevant and employ multi-discipline methodologies, so our research will provide better an understanding on how to best alleviate drug addiction. Ultimately, our preclinical findings will be translated to clinical research by identifying therapeutic targets to advance the pharmacological treatment paradigm for alcoholism.
 
Pharmacometabolomics and pharmacoproteomics for neurological disorders.
We have studied drug effocacy biomarker studies using metabolomics and protoemics to elucidate pharmacological intervention in neurological disorders including Parkinson’s disease and bipolar disorders. We have examined blood metabolite or tissue protein changes as a result of medication treatment and have found a possible metabolism in alcoholism patients that is associated with a positive outcome. The goal of pharmacometabolomics and pharmacoproteomics is to link the optimum physiological condition of a patient to a pharmaceutical treatment in disease. We believe that both pharmacometabolomics and pharmacoproteomics research will help to identify the best treatment option for a specific sub-population and contribute to the development of drug efficacy biomarker for personalized medicine in neurological disorders.

Publications

Selected Publications

1. Nam HW, Park SJ, Pyo HS, Paeng KJ. Applied analysis for metabolic profiling of trace-level amino acid in biological fluid. Anal Sci & Technol 16: 349-355, 2003.

2. Kang D, Nam HW, Kim YS, Moon MH. Dual-purpose sample trap for on-line strong cation- exchange chromatography/reversed-phase liquid chromatography/tandem mass spectrometry for shotgun proteomics. Application to the human Jurkat T-cell proteome. J Chromatogr A 1070:193-200, 2005.

3. Nam HW, Simpson R, Kim YS. N-terminal isotope tagging with propionic anhydride: proteomic analysis of myogenic differentiation of C2C12 cells. J Chromatogr B Analyt Technol Biomed Life Sci 826:91-107, 2005.

4. Nam HW, Lee GY, Kim YS. Mass spectrometric identification of K210 essential for rat malonyl-CoA decarboxylase catalysis. J Proteome Res 5:1398-1406, 2006.

5. Yang WH, Kim JE, Nam HW, Ju JW, Kim HS, Kim YS, Cho JW. Modification of p53 with O-linked N-acetylglucosamine regulates p53 activity and stability. Nat Cell Biol 8:1074-1083, 2006.

6. Koo BK, Jung J, Jung H, Nam HW, Kim YS, Yee A, Lee W. Solution structure of the hypothetical novel-fold protein TA0956 from Thermoplasma acidophilum. Proteins 69: 444-447, 2007.

7. Matsumoto R*, Nam HW*, Agrawal GK, Kim YS, Iwahashi H, Rakwal R. Exploring novel function of yeast Ssa1/2p by quantitative profiling proteomics using nanoLC-MS/MS. J Proteome Res 6:3465-3474, 2007. (*:co-first author)

8. Furusawa T, Rakwal R, Nam HW, Hirano M, Shibato J, Kim YS, Ogawa Y, Yoshida Y, Kramer KJ, Kouzuma Y, Agrawal GK, Yonekura M. Systematic investigation of the hemolymph proteome of Manduca sexta at the fifth instar larvae stage using one- and two-dimensional proteomics platforms. J Proteome Res 7:938-959, 2008.

9. Kim MK, Kang MR, Nam HW, Bae YS, Kim YS, Chung IK. Regulation of telomeric repeat binding factor 1 binding to telomeres by casein kinase 2-mediated phosphorylation. J Biol Chem 283:14144-14152, 2008.

10. Horie K, Rakwal R, Hirano M, Shibato J, Nam HW, Kim YS, Kouzuma Y, Agrawal GK, Masuo Y, Yonekura M. Proteomics of two cultivated mushrooms Sparassis crispa and Hericium erinaceum provides insight into their numerous functional protein components and diversity. J Proteome Res 7:1819-1835, 2008.

11. Furusawa T, Rakwal R, Nam HW, Shibato J, Agrawal GK, Kim YS, Ogawa Y, Yoshida Y, Kouzuma Y, Masuo Y, Yonekura M. Comprehensive royal jelly (RJ) proteomics using one- and two-dimensional proteomics platforms reveals novel RJ proteins and potential phospho/glycoproteins. J Proteome Res 7:3194-3229, 2008.

12. Lim JC, Choi HI, Park YS, Nam HW, Woo HA, Kwon KS, Kim YS, Rhee SG, Kim K, Chae HZ. Irreversible oxidation of the active-site cysteine of peroxiredoxin to cysteine sulfonic acid for enhanced molecular chaperone activity. J Biol Chem 283:28873-28880, 2008.

13. Yang WH, Park SY, Nam HW, Kim DH, Kang JG, Kang ES, Kim YS, Lee HC, Kim KS, Cho JW. NFkappaB activation is associated with its O-GlcNAcylation state under hyperglycemic conditions. Proc Natl Acad Sci U S A 105:17345-17350, 2008. 

14. Seo JH, Lim JC, Lee DY, Kim KS, Piszczek G, Nam HW, Kim YS, Ahn T, Yoon CH, Kim KH, Chock PB, Chae HZ. A novel protective mechanism against irreversible hyperoxidation of peroxiredoxin: N alpha -terminal acetylation of human peroxiredoxin II. J Biol Chem 284: 13455-13465, 2009.

15. Kim TH, Kim DH, Nam HW, Park SY, Shim J, Cho JW. Tyrosylprotein sulfotransferase regulates collagen secretion in Caenorhabditis elegans. Mol Cells 29:413-418, 2010.

16. Kim DH, Budhavarapu V, Herrera CR, Nam HW, Kim YS, Yew PR. The CRL4CDT2 ubiquitin ligase mediates the proteolysis of CDK inhibitor XIC1 through a direct association with PCNA. Mol Cell Biol 30:4120-4133, 2010.

17. Park SY, Kim HS, Kim NH, Ji S, Cha SY, Kang JG, Ota I, Shimada K, Konishi N, Nam HW, Hong SW, Yang WH, Roth J, Yook JI, Cho JW. Snail1 is stabilized by O-GlcNAc modification in hyperglycemic condition. EMBO J 29:3787-3796, 2010.

18. Yong Y, Choi SW, Choi HJ, Nam HW, Kim JA, Jeong DU, Kim DY, Kim YS, Kim DW. Exogenous signal-independent nuclear IkB kinase activation triggered by Nkx3.2 enables constitutive nuclear degradation of IkB-a in chondrocytes. Mol Cell Biol 14:2802-2816, 2011.

19. Nam HW, Lee MR, Hinton DJ, Choi DS. Reduced effect of NMDA glutamate receptor antagonist on ethanol-induced ataxia and striatal glutamate levels in mice lacking ENT1. Neurosci Lett 479:277-281, 2010.

20. Chen J, Nam HW, Lee MR, Hinton DJ, Choi S, Kim T, Kawamura T, Janak PH, Choi DS. Altered glutamatergic neurotransmission in the striatum regulates ethanol sensitivity and intake in mice lacking ENT1. Behav Brain Res 208:636-642, 2010.

21. Ruby CL, Adams CA, Knight EJ, Nam HW, Choi DS.  An Essential role for adenosine signaling in alcohol abuse. Curr Drug Abuse Rev 3:163-174, 2010.

22. Kim JH, Karpyak VM, Biernack JM, Nam HW, Lee MR, Preusse UW, Zillf P, Yoong GH, Colbyc C, Mrazek DA, Choi DS. Functional role of the polymorphic 647 T/C variant of ENT1 (SLC29A1) and its association with alcohol withdrawal seizures. PLoS One 6: e16331, 2011.

23. Asatryan L, Nam HW, Lee MR, Thakkar MM, Dar MS, Davies DL, Choi DS. Implication of the purinergic system in alcohol use disorders. Alcohol Clin Exp Res 35:584-594, 2011.

24. Nam HW, Lee MR, Zhu Y, Wu J, Hinton DJ, Choi S, Kim T, Hammack N, Yin JC, Choi DS. Type 1 equilibrative nucleoside transporter regulates ethanol drinking through accumbal N-Methyl-D-Aspartate Receptor signaling. Biol Psychiatry 69:1043-1051, 2011. Selected as 10 top-ranking articles in Biological Psychiatry 2011.

25. Nam HW, McIver SM, Hinton DJ, Thakkar MM, Sari Y, Parkinson FE, Haydon P, Choi DS. Adenosine and glutamate signaling in neuron-glia interaction: Implication in alcoholism and sleep disorders. Alcohol Clin Exp Res 36:1117-1125, 2012.

26. Nam HW, Hinton DJ, Choi S, Kang N, Chang SY, Choi DS. Adenosine transporter ENT1 regulates the acquisition of goal-directed behavior and ethanol drinking through A2A Receptor in the dorsomedial striatum. J Neurosci 33:4329-4338, 2013.

27. Nam HW, Bruner RC, Choi DS. Adenosine signaling in striatal circuits and alcohol use disorders. Mol Cells 36:3 195-202, 2013.

28. Nam HW, Karpyak VM, Li X, Walker DL, Hinton DJ, Choi H, Abulseoud OA, Frye MA, Mrazek DA, Choi DS. Elevated baseline serum glutamate as a pharmacometabolomic biomarker for acamprosate treatment outcome in alcohol dependent subjects. Transl Psychiatry, 5, e621, 2015. -Highlighted in NARSAD 2015 Summer Quarterly

29. Reker AN, Oliveros A, Hinton DJ, Kim T, Bruner RC, Sullivan JM, Choi DS, Goeders NE, Nam HW. Accumbal Neurogranin Regulates mGluR5 Mediated NMDAR Hypo-function and Motivation Related to Ethanol Seeking. Neurophamacology,131: 58-67, 2018  

30. Germany CE, Reker AN, Hinton DJ, Oliveros A, Smith K, Cvek U, Choi DS, Nam HW. Pharmacoproteomics identifies the drug efficacy mechanism in acamprosate treatment and alcoholism. Proteomics, 18(7), e1700417, 2018

31. Chandra M, Escalante-Alcaldeb D, Bhuiyan MS, Orr AW, Kevil C, Morrisd AJ, Nam HW, Dominic P, McCarthy KJ, Miriyala S, Panchatcharama M. Cardiac-specific inactivation of LPP3 in mice leads to myocardial dysfunction and heart failure. Redox Biology 14:261-271, 2018

32. Sreedhar A, Cassell T, Smith P, Lu D, Nam HW, Lane AN, Zhao Y. UCP2 Overexpression Redirects Glucose into Anabolic Metabolic Pathways. Proteomics, 19(4): e1800353, 2019

33. Sullivan JM 3rd, Grant CA, Reker AN, Nahar L, Goeders NE, Nam HW. Neurogranin regulates sensorimotor gating through cortico-striatal circuitry. Neurophamacology,150: 91-99, 2019  

34. Nahar L, Grant CG, Hewett CN, Cortes D, Reker AN, Choi DS, Nam HW. Regulation of Pv-Specific Interneurons in the Medial Prefrontal Cortex and Alcohol-Seeking Behaviors. Neuropharmacology, Under Revision 2019  

35. Nam HW, Grant CG, Jorgensen A, Trutschl M, Cvek U. Neurogranin regulates alcohol sensitivity through AKT pathway in the nucleus accumbens. Proteomics, In Press, 2019  

 

team

Vino T. Cheriyan, PhD (Postdoctoral Fellow)

Ashton Jorgensen (Graduate Student)

Lauren McHan (Student Worker)

Lailun Nahar (Graduate Student)

positions

Post-doctoral Fellows

While we are not currently recruiting Post-doctoral Fellows, quality candidates will always be considered. To inquire about opportunities, contact Dr. Nam at hnam@lsuhsc.edu.

 

Graduate Students

Graduate Students interested in conducting research in the Nam Lab should contact Dr. Nam at hnam@lsuhsc.edu.

 

Undergraduate Research Assistants

We are not currently hiring any additional undergraduates. However, positions can become available in the summer.

 

Medical Students, Residents, and Fellows

The Nam Lab has a number of research projects available for any Medical Students, Residents, and Fellows interested in drug addiction and alcoholism.

 

Nam's Lab