Alexander Lab

Contact Us

LSU Health Shreveport
Department of Molecular & Cellular Physiology
1501 Kings Hwy
Shreveport, LA 71103

 

Email: Jalexa@lsuhsc.edu
Office: (318)675-4151
Lab: (318)675-4150
Fax: (318)675-6005

J. Steven Alexander, PhD

Professor of Molecular and Cellular Physiology
 

Bachelor of Arts (1984) - Boston University
PhD, Vascular Physiology (1989) - Boston University
Post-Doctoral Fellow, (1993) - Vanderbilt University

News

Research

I have spent my research career investigating the vascular physiology and pathophysiology of endothelial inflammatory mechanisms cells in tissue injury and their contributions to disease. In recent years, my laboratory has focused on stem cell protection and restitution of tissues against diverse forms of acute ischemic and inflammatory injury using both mouse models of stroke and inflammatory bowel disease and cell models derived from human and mouse tissues as well. The current proposal focuses on mechanisms underlying protection against stroke injury; our lab has a track history of studying forms of central nervous system vascular injury and blood brain barrier including a recent patent on protection against ischemic injury. We have also been funded to work in this area and perform all of the molecular analyses described in the current proposal using stem cells. We also use these stem cells in synthetic tissues and 3D printed models. In these endeavors I have been privileged to act as a mentor for many trainees who are now independent investigators. 

Publications

Selected Publications

  1. Li W, Maloney RE, Circu ML, Alexander JS, Aw TY. Free Radic Biol Med. 2013 Jan; 54:51-61. Acute carbonyl stress induces occludin glycation and brain microvascular endothelial barrier dysfunction: role for glutathione-dependent metabolism of methylglyoxal.
  2. Yi P, Schrott L, Castor TP, Alexander JS. Bryostatin-1 vs. TPPB: dose-dependent APP processing and PKC-α, -δ, and -ε isoform activation in SH-SY5Y neuronal cells. J Mol Neurosci. 2012 Sep; 48(1):234-44. 
  3. Carpenter AC and Alexander JS. Endothelial PKC delta activation attenuates neutrophil transendothelial migration. Inflamm Res 57(5):216-29, 2008. This report served as the basis of our recent patent on Bryostatin-1 in’ Transplantation Therapy’.
  4. Chaitanya GV, Minagar A, Alexander JS. Neuronal and astrocytic interactions modulate brain endothelial properties during metabolic stresses of in vitro cerebral ischemia. Cell Commun Signal. 2014; 12:7. 

Complete List of my Published Work in MyBibliography: LEARN MORE
 

Team

Winny Yun, Ph.D.

Post-Doctoral Fellow
 

Mansoureh Barzegar

Graduate Assistant
 

Luke White

Graduate Assistant

Positions

Post-doctoral Fellows

While we are not currently recruiting Post-doctoral Fellows, quality candidates will always be considered.  To enquire about opportunities, contact Dr. Alexander at jalexa@lsuhsc.edu.

Graduate Students

Graduate students interested in conducting research in the Alexander lab should review the current laboratory research directions and contact Dr. Alexander at jalexa@lsuhsc.edu.

Undergraduate Research Assistants

We are not currently hiring any additional undergraduates. However, positions can become available during the summer.

Medical Students, Residents, and Fellows

The Alexander laboratory has a number of research projects available for any Medical Students, Residents, and Fellows. Those interested in learning more about opportunities in the Alexander lab, should contact Dr. Alexander directly at jalexa@lsuhsc.edu.