Research

Faculty members working within the Department of Biochemistry and Molecular Biology at the Louisiana State University Health Shreveport School of Medicine conduct research on the biochemical and molecular bases of disease (cancer, diabetes and neurological disorders), cell signaling cascades, epigenetics and enzymology. Areas of faculty research include aminoacyl-tRNA synthetases, cell cycle and DNA repair, epigenetics, gene regulation, molecular biology, signal transduction mechanisms, prostate cancer, melanoma, Parkinson’s disease, GABA, natural products and high throughput methods for therapeutic discovery.  Faculty members take pride in their extensive research collaborations with the school’s other academic and clinical departments and with investigators at other institutions in the U.S. and in other countries. Faculty are funded by grants from the National Institutes of Health, the National Science Foundation, the Department of Defense and from private agencies.

Current Studies

Cancer Biology

Cancer Biology

 ARRIGO DE BENEDETTI

 Altered protein synthesis in solid tumors
 SHILE HUANG

 mTOR signaling in tumorigenesis and metastasis

 HARI KOUL  Regulation of the Warburg effect in cancer; molecular targets in prostate and pancreatic cancer
 NANCY LEIDENHEIMER  Role of GABA shunt in cancer cell metabolic reprogramming
 SERGEY SLEPENKOV

 Anticancer activity of the small molecule tetrandine and its interaction with protein targets in prostate cancer cells

 STEPHAN N. WITT  Alpha Synuclein and melanoma
 XIUPING YU  Prostate cancer and prostatic disease

 

Contact Us

Department of Biochemistry & Molecular Biology
Phone: (318) 675-5160
Fax: (318) 675-5180
Email: Admissions-BMB@lsuhsc.edu

Cell Cycle and Cell Signaling

Cell Cycle and Cell Signaling

 ARRIGO DE BENEDETTI

 Gene expression; radioresistance by the protein kinase Tousled; gene therapy
 SHILE HUANG  mTOR signaling in tumorigensis and metastasis
 BRENT REED

 Functions of GLUT1CBP (GIPC), a myosin VI adapter protein

 LUCY ROBINSON  Control of cell growth and division, protein phosphorylation, vesicular trafficking and yeast genetics
GULSHAN SUNAVALA-DOSSABHOY  Genotoxin-mediated DNA damage and repair, and salivary function

Contact Us

Department of Biochemistry & Molecular Biology
Phone: (318) 675-5160
Fax: (318) 675-5180
Email: Admissions-BMB@lsuhsc.edu

Enzymes, Proteins and Protein Engineering

Enzymes, Proteins and Protein Engineering

 ERIC FIRST

 Aminoacylation of tRNA; expansion of the genetic code; Charcot-Marie-Tooth disorder; enzyme catalysis; protein engineering
 HARI KOUL

 Mechanisms of oxalate nephrotoxicity

 NANCY LEIDENHEIMER  Bioenergetics of the GABA shunt, A TCA cycle bypass mechanism
 GULSHAN SUNAVALA-DOSSABHOY  Protein and small molecule therapies to suppress radiation damage to
 non-cancerous tissues
 KELLY TATCHELL

 Type 1 protein phosphatase (PP1) in the yeast Saccharomyces cerevisiae

 STEPHAN N. WITT  Vessicle trafficking and molecular bases of diseases

 

Contact Us

Department of Biochemistry & Molecular Biology
Phone: (318) 675-5160
Fax: (318) 675-5180
Email: Admissions-BMB@lsuhsc.edu

Epigenetics and Transcription

Contact Us

Department of Biochemistry & Molecular Biology
Phone: (318) 675-5160
Fax: (318) 675-5180
Email: Admissions-BMB@lsuhsc.edu

Neurobiology and Neurodegeneration

Neurobiology and Neurodegeneration

 SHILE HUANG

Neuronal apoptosis
 NANCY LEIDENHEIMER Function, trafficking and degradation of Gamma-aminobutyric (GABA) receptors
 STEPHAN N. WITT  Alpha Synuclein and Parkinson's disease

 

Contact Us

Department of Biochemistry & Molecular Biology
Phone: (318) 675-5160
Fax: (318) 675-5180
Email: Admissions-BMB@lsuhsc.edu

Biochemistry & Molecular Biology Research