Welcome to the Glasscock Lab!

We are the Cardiorespiratory Neurogenetics Laboratory at the Louisiana State University Health Sciences Center.

We are focused on understanding the genes and mechanisms underlying epilepsy and sudden unexpected death in epilepsy (SUDEP). Epilepsy is the 4th most common neurological disorder affecting about 1 in 26 Americans during their lifetime. Epilepsy is characterized by the presence of recurrent unprovoked seizures due to abnormal electrical activity in the brain. Genetics and heredity play an important role in the development of epilepsy. One of the goals of the lab is to identify the genes and combinations of genes that determine whether an individual will develop epilepsy.

People with epilepsy have an increased risk of dying suddenly for unknown reasons. These deaths are classified as sudden unexpected death in epilepsy (SUDEP) and represent the leading cause of epilepsy-related mortality. The exact causes of SUDEP are poorly understood, but the leading explanation is that seizures evoke respiratory failure or cardiac arrhythmias that culminate in death. One of the focuses of the lab is to better understand how epilepsy can alter the brain’s control of cardiorespiratory function increasing the risk of SUDEP. In addition, we are striving to develop new therapeutics to prevent SUDEP and better biomarkers to predict those with high risk.

To explore these questions, we study genetic mouse models of epilepsy, utilizing a wide array of in vivo, ex vivo, and in vitro electrophysiological techniques, pharmacology, histology, and molecular analyses.

Our research has been supported by the National Heart Lung and Blood Institute (NHLBI), the National Institute of Neurological Disorders and Stroke (NINDS), Citizens United for Research in Epilepsy (CURE), Epilepsy Foundation, and American Heart Association (AHA).
Recent Lab News

The Glasscock lab was awarded a 4-year research grant (R01) from the National Institutes of Health (NIH) to fund a study of “Neurocardiac mechanisms of epilepsy with high risk of SUDEP.” (July 1, 2017)

Hemangini Dhaibar was awarded an Ike Muslow Predoctoral Fellowship to fund her thesis project examining the role of respiratory abnormalities in the Knca1-null mouse model of SUDEP. (May 31, 2017)

Krystle Trosclair passed her preliminary and qualifying exams to officially become a PhD doctoral candidate. (May 26, 2017)

Hemangini Dhaibar won 1st place senior student poster presentation and Krystle Trosclair won 2nd place oral presentation at the annual LSU Graduate Research Day. (May 5, 2017)

The Glasscock lab was awarded a 5-year research grant (R01) from the National Institutes of Health (NIH) to fund a study of “Respiratory mechanisms of epilepsy with high risk of SUDEP,” which you can learn more about in this video. (April 1, 2017)

Krystle Trosclair was awarded a travel award to the American Association of Anatomists (AAA) Annual Meeting at the Experimental Biology Conference in Chicago, IL on April 22-25. She was also selected as a Poster Award finalist for an AAA Graduate Student Poster Presentation Award. (February 1, 2017)