COBRE Award Announcement - NIH/NIGHMS Center of Biomedical Research Excellence
Center for Redox Biology and Cardiovascular Disease
LSU Health Shreveport was awarded a five-year, $10.5 million Centers of Biomedical Research Excellence (COBRE) grant by the National Institutes of Health. The NIH’s COBRE initiative aims to strengthen an institution’s biomedical research infrastructure through the establishment of a thematic multi-disciplinary center. The $10,580,176 grant will fund the Center for Redox Biology and Cardiovascular Disease project at LSUHS and promote research on campus in the redox regulation of cardiovascular disease.
Cardiovascular disease is the leading cause of death and disability in the United States, and Louisiana ranks in the top five of states most affected by cardiovascular disease. The COBRE Center for Redox Biology and Cardiovascular Disease will advance understanding of redox biology control of heart and vascular disease processes that may lead to new and better ways to detect or treat cardiovascular disease.
The Center for Cardiovascular Diseases and Sciences at LSU Health Shreveport has assembled investigators with advanced knowledge and research expertise across several departments to address redox biology mechanisms contributing to cardiovascular disease. The principal investigator of the project is Dr. Chris Kevil, Vice Chancellor for Research and a Professor in the Department of Pathology. Key research personnel include: Dr. Christopher Pattillo, Assistant Professor in the Department of Molecular and Cellular Physiology; Dr. Manikandan Panchatcharam, Assistant Professor in the Department of Cellular Biology and Anatomy; and Dr. Hyung Nam, Assistant Professor in the Department of Pharmacology, Toxicology and Neuroscience. Dr. Wayne Orr, Director of the Center for Cardiovascular Diseases and Sciences, Dr. Karen Stokes, Assistant Director of the Center for Cardiovascular Diseases and Sciences, and Dr. Andrew Yurochko, a Professor and member of the Centers Research Committee, were also instrumental in helping to secure the COBRE grant.
Cardiovascular disease remains the primary cause of morbidity and mortality for United States citizens, as well as people across the globe. Moreover, the burden of cardiovascular disease in Louisiana is stark leading to a quarter of all deaths in the state. Research into cardiovascular pathophysiology is an important priority at LSU Health Sciences Center Shreveport with the recently formed Center for Cardiovascular Diseases and Sciences (CCDS). The CCDS has enabled nucleation of campus cardiovascular research through various programs and initiatives.
However, specific efforts that facilitate junior faculty research program funding and advances in professional development remain underdeveloped. The objective of this COBRE Center for Redox Biology and Cardiovascular Disease is to establish a nationally recognized research and training program that develops federally funded junior faculty research while revealing new insights into cardiovascular pathology. The major goals of this COBRE program are to: 1) establish a strong and consistent mentorship and professional development program, 2) establish advanced research core facilities, and 3) advance mechanistic understanding of redox biology regulation of cardiovascular pathophysiology. Pursuit of the following specific aims will enable successful implementation of the proposed COBRE program.
The specific aims for this COBRE application are:
- To provide leadership for developing mentoring and training programs, professional development, state of the art research infrastructure to advance scientific excellence in redox biology and cardiovascular disease leading to nationally recognized research discoveries and achievements from the CCDS and LSU Health Sciences Center Shreveport.
- Establish a group of Core facilities including an Administration Core (Core A), an Animal Model & Histology Core (Core B), and a Redox Molecular Signaling Core (Core C) that advance mentorship training and research excellence at LSU Health Sciences Center Shreveport.
- To establish and implement advisory committees (both internal and external) that provides guidance to program junior faculty and COBRE leaders.
- To establish a group of junior faculty projects investigating redox biology mechanisms of cardiovascular disease that will be competitive for independent federal funding.
- To establish and operate a Pilot Grant Program for promising young investigators currently at the institution, as well as those who are recruited in the future.
- To establish and execute scientific meetings, research education, and professional development seminars that further scientific excellence at LSU Health Sciences Center Shreveport and provide advanced training for institutional faculty.
- To ensure that COBRE Center programs, initiatives, policies and reporting formats are clearly developed and integrated within the institution according to federal granting agency policies and deadlines.
The COBRE Ordering and Receiving Process is outlined in this document: COBRE-Ordering-and-Receiving-Process-3.12.2018.docx.
Please use the LAB SUPPLIES ORDER FORM to order supplies.
The Center for Redox Biology and Cardiovascular Disease is supported by the National Institute of General Medical Sciences of the National Institutes of Health under Award Number P20GM121307.