Michael F. Salvatore, Ph.D.
BA, Ohio Wesleyan University, 1988
PhD, Neuroscience, Louisiana State University Health Sciences Center-New Orleans 2000.
Postdoctoral, University of Kentucky, Morris K. Udall Parkinson’s Disease Research Center of Excellence and Molecular and Cellular Basis of Brain Aging Postdoctoral Fellowships, 2000-2005.
Identifying the functional contributions of dopamine- and glutamate-regulating proteins in regulating the function of the nigrostriatal system in aging-related movement disorders and Parkinson’s disease. We use multidisplinary approaches in studies to address these goals. These approaches include rigorous locomotor assessment throughout the lifespan, interventions in the brain circuitry and its molecular dynamics, and identifying post-translational modifications that impact locomotor function and Parkinson’s disease progression.
Research Goals and Curriculum Vitae
Targeting nigral tyrosine hydroxylase to improve locomotion in aging, NIH, National Institute on Aging.
Completed Extramural Support
The American Federation for Aging Research, Role of tyrosine hydroxylase phosphorylation in age-related bradykinesia, 2007-2009.
Current Lab Members
Tanya Chotibut, Graduate Student
The impact of glutamate on Parkinson’s disease progression
Jennifer Arnold, Graduate Student
Exercise impact on dopamine and glutamate regulation
Victoria Fields, Research Assistant
Tamara McInnis, Research Assistant
Previous Lab Members
Brandon Scott Pruett, Ph.D.
Molecular strategies to improve aging-related bradykinesia
Randy Vince, Medical Student, Research Internship
Danielle Nodruft, Medical Student, Research Internship
Catie Owens, Parkinson's Disease Foundation Fellowship, 2013
Recent Peer-reviewed publications (past 5 years)
Salvatore, M.F. ser31 tyrosine hydroxylase phosphorylation parallels differences in dopamine recovery in nigrostriatal pathway following 6-OHDA lesion. J Neurochem, DOI: 10.1111/jnc.12652, 2014.
Chotibut, T., Davis, R.W., Frenchek, Z., Gurwara, S., Arnold, J.C., Bondana, V., Geddes, J.W. Salvatore, M.F. Ceftriaxone increases glutamate uptake and reduces striatal tyrosine hydroxylase loss in 6-OHDA Parkinson’s model. Mol Neurobiol, DOI 10.1007/s12035-013-8598-0, 2013.
Pruett, B.S., Salvatore, M.F. Nigral GFRα-1 infusion in aged rats increases locomotor activity, nigral tyrosine hydroxylase, and dopamine content in synchronicity. Mol Neurobiol, 47, 989-999, 2013.
Chotibut, T.*, Apple, D.M.*,Jefferis, R., Salvatore, M.F. Dopamine transporter loss in 6-OHDA Parkinson’s model is unmet by parallel reduction in dopamine uptake. PLoS ONE, 7 (12) e52322, 2012.
Salvatore, M.F., Pruett, B.S., Dempsey, C., Fields, V. Comprehensive profiling of dopamine regulation in substantia nigra and ventral tegmental area. J Visualized Exp. e4171, DOI: 10.3791/4171 2012.
Salvatore, M.F., Davis, R.W., Arnold, J.C., Chotibut, T. Transient striatal GLT-1 blockade increases EAAC1 expression, glutamate reuptake, and decreases tyrosine hydroxylase phosphorylation at ser19. Exp Neurol, 234, 428-436, 2012.
Salvatore, M.F., Pruett, B.S. Dichotomy of tyrosine hydroxylase and dopamine regulation between somatodendritic and terminal field areas of nigrostriatal and mesoaccumbens pathways. PLoS ONE. 7 (1), e29867, 2012.
Goldberg, N.R.S., Fields, V., Pflibsen, L., Salvatore, M.F., Meshul, C.K. Social enrichment attenuates nigrostriatal lesioning and reverses motor impairment in a progressive 1-methyl-2-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson’s disease. Neurobiol Dis, 45, 1051-1067, 2012.
"Targeting Tyrosine Hydroxylase to Improve Bradykinesia"
Salvatore Lab, January 2012